General Toxicity Notes
Anticholinergic side effects cause urinary retention and orthostatic hypotension. Drug may cause confusion and excessive sedation.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
24/No data
Plasma Protein Binding %
90-96
Volume Of Distribution L/Kg
31
Dose For Normal Renal Function
50-150 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
von Moltke LL, Greenblatt DJ, Shader RI. Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications. Clin Pharmacokinet. 1993; 24: 141-60. [PMID: 8471078]