General Toxicity Notes
Anticholinergic side effects cause urinary retention and orthostatic hypotension. Drug may cause confusion and excessive sedation.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
8-25/10-30
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
9-33
Dose For Normal Renal Function
25 mg q8h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Coccaro EF, Siever LJ. Second generation antidepressants: a comparative review. J Clin Pharmacol. 1985; 25: 241-60. [PMID: 3891797] / el-Yazigi A, Chaleby K. Steady-state kinetics of doxepin and imipramine in Saudi patients with interethnic comparison. Psychopharmacology (Berl). 1988; 95: 63-7. [PMID: 3133701] / Sallee FR, Pollock BG. Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990; 18: 346-64. [PMID: 2185906]