General Toxicity Notes
Anticholinergic side effects cause urinary retention and orthostatic hypotension. Drug may cause confusion and excessive sedation.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
18-26/No data
Plasma Protein Binding %
92
Volume Of Distribution L/Kg
10-50
Dose For Normal Renal Function
100-200 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Kennedy SH, Craven JL, Rodin GM, Roin GM. Major depression in renal dialysis patients: an open trial of antidepressant therapy. J Clin Psychiatry. 1989; 50: 60-3. [PMID: 2644243] / Sallee FR, Pollock BG. Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990; 18: 346-64. [PMID: 2185906]