Amoxapine

General Toxicity Notes
Anticholinergic side effects cause urinary retention and orthostatic hypotension. Drug may cause confusion and excessive sedation.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
8-30/No data
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
75-200 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Calvo B, Garc&#237; a MJ, Pedraz JL, Mari&#241; o EL, Dom&#237; nguez-Gil A. Pharmacokinetics of amoxapine and its active metabolites. Int J Clin Pharmacol Ther Toxicol. 1985; 23: 180-5. [PMID: 3997304]
Toxicity Notes
T1/2 of active metabolite is 30 hours.