General Toxicity Notes
Anticholinergic side effects cause urinary retention and orthostatic hypotension. Drug may cause confusion and excessive sedation.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
24-40/Unchanged
Plasma Protein Binding %
96
Volume Of Distribution L/Kg
6-36
Dose For Normal Renal Function
25 mg q8h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Sallee FR, Pollock BG. Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet. 1990; 18: 346-64. [PMID: 2185906] / Tasset JJ, Singh S, Pesce AJ. Evaluation of amitriptyline pharmacokinetics during peritoneal dialysis. Ther Drug Monit. 1985; 7: 255-7. [PMID: 4049459]