Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
24/No data
Plasma Protein Binding %
97
Volume Of Distribution L/Kg
25
Dose For Normal Renal Function
50-200 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Cohen LJ. Rational drug use in the treatment of depression. Pharmacotherapy. 1997; 17: 45-61. [PMID: 9017765]