Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
10-16/30
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
13
Dose For Normal Renal Function
20-60 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50-75% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Nemeroff CB. The clinical pharmacology and use of paroxetine, a new selective serotonin reuptake inhibitor. Pharmacotherapy. 1994; 14: 127-38. [PMID: 8197030]