Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
12-15/Unchanged
Plasma Protein Binding %
77
Volume Of Distribution L/Kg
25
Dose For Normal Renal Function
100 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
van Harten J. Overview of the pharmacokinetics of fluvoxamine. Clin Pharmacokinet. 1995; 29 Suppl 1: 1-9. [PMID: 8846617] / Perucca E, Gatti G, Spina E. Clinical pharmacokinetics of fluvoxamine. Clin Pharmaco-kinet. 1994; 27: 175-90. [PMID: 7988100]