General Toxicity Notes
Orthostatic hypotension, extrapyramidal symptoms, and confusion can occur.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
9-12/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
Large
Dose For Normal Renal Function
20-100 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable, [D]
References
Stavchansky S, Wallace JE, Geary R, Hecht G, Robb CA, Wu P. Bioequivalence and pharmacokinetic profile of promethazine hydrochloride suppositories in humans. J Pharm Sci. 1987; 76: 441-5. [PMID: 3625487]
Toxicity Notes
Excessive sedation may occur in ESRD.