General Toxicity Notes
Orthostatic hypotension, extrapyramidal symptoms, and confusion can occur.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
11-42/Unchanged
Plasma Protein Binding %
91-99
Volume Of Distribution L/Kg
8-160
Dose For Normal Renal Function
300-800 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Indraprasit S, Sooksriwongse C. Effect of chlorpromazine on peritoneal clearances. Nephron. 1985; 40: 341-3. [PMID: 4010849] / Verbeeck RK, Cardinal JA. Plasma protein binding of salicylic acid, phenytoin, chlorpromazine, propranolol and pethidine using equilibrium dialysis and ultracentrifugation. Arzneimittelforschung. 1985; 35: 903-6. [PMID: 4026915]