Excreted Unchanged %
Hepatic (renal)
Half-Life (Normalesrd) Hours
9-11/Unchanged
Plasma Protein Binding %
0-30
Volume Of Distribution L/Kg
0.5-0.8
Dose For Normal Renal Function
1.2-1.6 g q24h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6h [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q9-12h [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
q12-18h [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Hassan E. Treatment of meprobamate overdose with repeated oral doses of activated charcoal. Ann Emerg Med. 1986; 15: 73-6. [PMID: 3942359] / Jacobsen D, Wiik-Larsen E, Saltvedt E, Bredesen JE. Meprobamate kinetics during and after terminated hemoperfusion in acute intoxications. J Toxicol Clin Toxicol. 1987; 25: 317-31. [PMID: 3669117]
Toxicity Notes
Excessive sedation. Excretion enhanced by forced diuresis.