Triazolam

General Toxicity Notes
May cause excessive sedation and encephalopathy in ESRD.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
2-4/Unchanged
Plasma Protein Binding %
85-95
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
0.25-0.50 mg hs
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Friedman H, Greenblatt DJ, Burstein ES, Harmatz JS, Shader RI. Population study of triazolam pharmacokinetics. Br J Clin Pharmacol. 1986; 22: 639-42. [PMID: 3567010] / Gaudreault P, Guay J, Thivierge RL, Verdy I. Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment. Drug Saf. 1991; 6: 247-65. [PMID: 1888441] / Greenblatt DJ. Benzodiazepine hypnotics: sorting the pharmacokinetic facts. J Clin Psychiatry. 1991; 52 Suppl: 4-10. [PMID: 1680125] / Greenblatt DJ. Pharmacokinetics and pharmacodynamics. Hosp Pract (Off Ed). 1990; 25 Suppl 2: 9-15; discussion 16-8. [PMID: 2114417] / Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI. Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam. Arch Gen Psychiatry. 1989; 46: 326-32. [PMID: 2564763] / Jochemsen R, Breimer DD. Pharmacokinetics of temazepam compared with other benzodiazepine hypnotics&#151; some clinical consequences. Acta Psychiatr Scand Suppl. 1986; 332: 20-31. [PMID: 2883825] / Kroboth PD, Smith RB, Silver MR, Rault R, Sorkin MI, Puschett JB, et al. Effects of end stage renal disease and aluminium hydroxide on triazolam pharmacokinetics. Br J Clin Pharmacol. 1985; 19: 839-42. [PMID: 2862896] / Smith RB, Kroboth PD, Varner PD. Pharmacodynamics of triazolam after intravenous administration. J Clin Pharmacol. 1987; 27: 971-9. [PMID: 3437069] / Treiman DM. Pharmacokinetics and clinical use of benzodiazepines in the management of status epilepticus. Epilepsia. 1989; 30 Suppl 2: S4-10. [PMID: 2670537]
Toxicity Notes
Protein binding correlates with alpha-1 acid glycoprotein concentration.