General Toxicity Notes
May cause excessive sedation and increase osteomalacia in ESRD. Charcoal hemoperfusion and hemodialysis more effective than peritoneal dialysis. For poisoning.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
3.8/6-18
Plasma Protein Binding %
72-86
Volume Of Distribution L/Kg
1.0-1.5
Dose For Normal Renal Function
Anesthesia induction (individualized)
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
75% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Browne TR. The pharmacokinetics of agents used to treat status epilepticus. Neurology. 1990; 40: 28-32. [PMID: 2185438]