General Toxicity Notes
May cause excessive sedation and increase osteomalacia in ESRD. Charcoal hemoperfusion and hemodialysis more effective than peritoneal dialysis. For poisoning.
Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
18-48/Unchanged
Plasma Protein Binding %
60-70
Volume Of Distribution L/Kg
1.0
Dose For Normal Renal Function
30 mg q6-8h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [B]
References
Bironneau E, Garrec F, Kergueris MF, Testa A, Nicolas F. Hemodiafiltration in pentobarbital poisoning. Ren Fail. 1996; 18: 299-303. [PMID: 8723368] / Browne TR. The pharmacokinetics of agents used to treat status epilepticus. Neurology. 1990; 40: 28-32. [PMID: 2185438] / Wermeling D, Record K, Bell R, Porter W, Blouin R. Hemodialysis clearance of pentobarbital during continuous infusion. Ther Drug Monit. 1985; 7: 485-7. [PMID: 4082247]