Excreted Unchanged %
10-20(renal)
Half-Life (Normalesrd) Hours
6-11/No data
Plasma Protein Binding %
89-95
Volume Of Distribution L/Kg
1-2
Dose For Normal Renal Function
150-400 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Browne TR. The pharmacokinetics of agents used to treat status epilepticus. Neurology. 1990; 40: 28-32. [PMID: 2185438] / DeVane CL. Pharmacokinetics of the newer antidepressants: clinical relevance. Am J Med. 1994; 97: 13S-23S. [PMID: 7992822] / Preskorn SH. Comparison of the tolerability of bupropion, fluoxetine, imipramine, nefazodone, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry. 1995; 56 Suppl 6: 12-21. [PMID: 7649968]