Excreted Unchanged %
Hepatic
Half-Life (Normalesrd) Hours
10-21/No data
Plasma Protein Binding %
82-88
Volume Of Distribution L/Kg
27-36
Dose For Normal Renal Function
100 mg q8h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
DeVane CL. Pharmacokinetics of the selective serotonin reuptake inhibitors. J Clin Psychiatry. 1992; 53 Suppl: 13-20. [PMID: 1531816] / DeVane CL. Pharmacokinetics of the newer antidepressants: clinical relevance. Am J Med. 1994; 97: 13S-23S. [PMID: 7992822] / Goodnick PJ. Pharmacokinetics of second generation antidepressants: bupropion. Psychopharmacol Bull. 1991; 27: 513-9. [PMID: 1813898] / Laizure SC, DeVane CL, Stewart JT, Dommisse CS, Lai AA. Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose. Clin Pharmacol Ther. 1985; 38: 586-9. [PMID: 3931955] / Posner J, Bye A, Dean K, Peck AW, Whiteman PD. The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses. Eur J Clin Pharmacol. 1985; 29: 97-103. [PMID: 3932079] / Preskorn SH. Comparison of the tolerability of bupropion, fluoxetine, imipramine, nefazodone, paroxetine, sertraline, and venlafaxine. J Clin Psychiatry. 1995; 56 Suppl 6: 12-21. [PMID: 7649968] / Suckow RF, Smith TM, Perumal AS, Cooper TB. Pharmacokinetics of bupropion and metabolites in plasma and brain of rats, mice, and guinea pigs. Drug Metab Dispos. 1986; 14: 692-7. [PMID: 2877828] / Welch RM, Lai AA, Schroeder DH. Pharmacological significance of the species differences in bupropion metabolism. Xenobiotica. 1987; 17: 287-98. [PMID: 3107223]