Excreted Unchanged %
Negligible
Half-Life (Normalesrd) Hours
0.5-1/Unchanged
Plasma Protein Binding %
95
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
20-60 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Naesdal J, Andersson T, Bodemar G, Larsson R, Regå rdh CG, Skå nberg I, et al. Pharmacokinetics of [14C]omeprazole in patients with impaired renal function. Clin Pharmacol Ther. 1986; 40: 344-51. [PMID: 3742939]