Half-Life (Normalesrd) Hours
0.5-1.3/Unchanged
Plasma Protein Binding %
30
Volume Of Distribution L/Kg
0.18-0.27
Dose For Normal Renal Function
0.08-0.1 mg/kg load, then 0.01-0.05 mg/kg q12-15min
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Miller RD. Vecuronium: a new nondepolarizing neuromuscular-blocking agent. Clinical pharmacology, pharmacokinetics, cardiovascular effects and use in special clinical situations. Pharmacotherapy. 1984; 4: 238-47. [PMID: 6150465] / Shanks CA, Avram MJ, Fragen RJ, O’ Hara DA. Pharmacokinetics and pharmacodynamics of vecuronium administered by bolus and infusion during halothane or balanced anesthesia. Clin Pharmacol Ther. 1987; 42: 459-64. [PMID: 2889555]