Excreted Unchanged %
40-60
Half-Life (Normalesrd) Hours
0.5-4/5.5
Plasma Protein Binding %
30-50
Volume Of Distribution L/Kg
0.22-0.39
Dose For Normal Renal Function
0.1-0.2 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
75% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Miller RD, Matteo RS, Benet LZ, Sohn YJ. The pharmacokinetics of d-tubocurarine in man with and without renal failure. J Pharmacol Exp Ther. 1977; 202: 1-7. [PMID: 195035]
Toxicity Notes
Large or repetitive doses may result in prolonged effect. Recurarization may occur.