Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
3/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
0.3-1.1 mg/kg load, then 0.04-0.07 mg/kg prn
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Bishop MJ, Hornbein TF. Prolonged effect of succinylcholine after neostigmine and pyridostigmine administration in patients with renal failure. Anesthesiology. 1983; 58: 384-6. [PMID: 6340560]
Toxicity Notes
Hyperkalemia in ESRD.