Excreted Unchanged %
80-90
Half-Life (Normalesrd) Hours
1.5-2.0/6
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
0.8-1.4
Dose For Normal Renal Function
60-1500 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
50% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
35% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
20% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Cronnelly R, Stanski DR, Miller RD, Sheiner LB. Pyridostigmine kinetics with and without renal function. Clin Pharmacol Ther. 1980; 28: 78-81. [PMID: 6993086]
Toxicity Notes
Renal excretion decreased by basic drugs.