Excreted Unchanged %
<0.3
Half-Life (Normalesrd) Hours
1.5/16.8
Plasma Protein Binding %
96-99
Volume Of Distribution L/Kg
8-19
Dose For Normal Renal Function
2.0-2.5 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, tirate, [B]
References
Nathan N, Debord J, Narcisse F, Dupuis JL, Lagarde M, Benevent D, et al. Pharmacokinetics of propofol and its conjugates after continuous infusion in normal and in renal failure patients: a preliminary study. Acta Anaesthesiol Belg. 1993; 44: 77-85. [PMID: 8310787]
Toxicity Notes
Green urine.