Excreted Unchanged %
30-40
Half-Life (Normalesrd) Hours
1.7-2.2/4.3-8.2
Plasma Protein Binding %
70-85
Volume Of Distribution L/Kg
0.15-0.38
Dose For Normal Renal Function
0.04-0.1 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, tirate, [D]
References
McLeod K, Watson MJ, Rawlins MD. Pharmacokinetics of pancuronium in patients with normal and impaired renal function. Br J Anaesth. 1976; 48: 341-5. [PMID: 1276000]
Toxicity Notes
Recurarization may occur up to 24 hours after dose.