Half-Life (Normalesrd) Hours
2.0-3.5/Unchanged
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
1.8-3.1
Dose For Normal Renal Function
1.0-4.5 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, tirate, [B]
References
Tsubo T, Sakai I, Okawa H, Ishihara H, Matsuki A. Ketamine and midazolam kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction syndrome. Intensive Care Med. 2001; 27: 1087-90. [PMID: 11497143]