Excreted Unchanged %
85-100
Half-Life (Normalesrd) Hours
2.3-2.7/6-20
Plasma Protein Binding %
30-70
Volume Of Distribution L/Kg
0.21-0.24
Dose For Normal Renal Function
0.5-1.5 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
75% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Avoid
References
Ramzan MI, Shanks CA, Triggs EJ. Gallamine disposition in surgical patients with chronic renal failure. Br J Clin Pharmacol. 1981; 12: 141-7. [PMID: 7306428]
Toxicity Notes
Recurarization may occur up to 24 hours after dose. If blockade not responsive to neostigmine (q.v.), dialysis may be useful.