Half-Life (Normalesrd) Hours
1/Unchanged
Plasma Protein Binding %
17
Volume Of Distribution L/Kg
0.18-0.23
Dose For Normal Renal Function
1-2 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Bevan DR, D’ Souza JD, Rouse JM, Caldwell J, Smith RL. Clinical pharmacokinetics and pharmacodynamics of fazadinium in renal failure. Eur J Clin Pharmacol. 1981; 20: 293-8. [PMID: 6118278] / Smith CE, Hunter JM. Anesthesia for renal transplantation: relaxants and volatiles. Int Anesthesiol Clin. 1995; 33: 69-92. [PMID: 7657381]