Excreted Unchanged %
24-38
Half-Life (Normalesrd) Hours
1.2-1.6/3.7
Plasma Protein Binding %
40
Volume Of Distribution L/Kg
0.12-0.22
Dose For Normal Renal Function
0.025-0.05 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, titrate
References
Cook DR, Freeman JA, Lai AA, Robertson KA, Kang Y, Stiller RL, et al. Pharmaco-kinetics and pharmacodynamics of doxacurium in normal patients and in those with hepatic or renal failure. Anesth Analg. 1991; 72: 145-50. [PMID: 1824669]