Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
0.3-0.4/Unchanged
Plasma Protein Binding %
40-50
Volume Of Distribution L/Kg
0.15-0.18
Dose For Normal Renal Function
0.4-0.5 mg/kg load, then 0.08-0.1 mg/kg q15-25min
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, tirate, [B]
References
Conner CS. Atracurium and vecuronium: two unique neuromuscular blocking agents. Drug Intell Clin Pharm. 1984; 18: 714-6. [PMID: 6148226] / Shearer ES, O’ Sullivan EP, Hunter JM. Clearance of atracurium and laudanosine in the urine and by continuous venovenous haemofiltration. Br J Anaesth. 1991; 67: 569-73. [PMID: 1751271]