Half-Life (Normalesrd) Hours
1.4-2.0/Unchanged
Plasma Protein Binding %
88-95
Volume Of Distribution L/Kg
0.3-1.0
Dose For Normal Renal Function
8-245 µg/kg load, then 0.5-3 µg/kg min
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, tirate, [D]
References
Van Peer A, Vercauteren M, Noorduin H, Woestenborghs R, Heykants J. Alfentanil kinetics in renal insufficiency. Eur J Clin Pharmacol. 1986; 30: 245-7. [PMID: 3086106]
Toxicity Notes
Seldom used because of newer congeners.