Metoclopramide

Excreted Unchanged %
10-22
Half-Life (Normalesrd) Hours
2.5-4.0/14-15
Plasma Protein Binding %
40
Volume Of Distribution L/Kg
2-3.4
Dose For Normal Renal Function
10-15 mg qid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
75% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Bateman DN. Clinical pharmacokinetics of metoclopramide. Clin Pharmacokinet. 1983; 8: 523-9. [PMID: 6360466]
Toxicity Notes
Extrapyramidal side effects increase in ESRD.