Excreted Unchanged %
30-35
Half-Life (Normalesrd) Hours
6/No data
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
2.0-2.5
Dose For Normal Renal Function
Acute: 1 g, then 0.5 g q4-12h
Second Dose
Chronic: 0.5-1 g q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
25-50% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Allain P, Mauras Y, Chaleil D, Simon P, Ang KS, Cam G, et al. Pharmacokinetics and renal elimination of desferrioxamine and ferrioxamine in healthy subjects and patients with haemochromatosis. Br J Clin Pharmacol. 1987; 24: 207-12. [PMID: 3620295]
Toxicity Notes
Severe allergic reactions including anaphylaxis. Neurotoxicity with impaired renal clearance.