Half-Life (Normalesrd) Hours
3-16/Unchanged
Plasma Protein Binding %
96-99
Volume Of Distribution L/Kg
3.5-7.4
Dose For Normal Renal Function
3-10 mg/kg q12h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [A]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, monitor serum concentration, [B]
References
Alloway RR, Isaacs R, Lake K, Hoyer P, First R, Helderman H, et al. Report of the American Society of Transplantation conference on immunosuppressive drugs and the use of generic immunosuppressants. Am J Transplant. 2003; 3: 1211-5. [PMID: 14510694] / Awni WM, Kasiske BL, Heim-Duthoy K, Rao KV. Long-term cyclosporine pharmacokinetic changes in renal transplant recipients: effects of binding and metabolism. Clin Pharmacol Ther. 1989; 45: 41-8. [PMID: 2642778] / Follath F, Wenk M, Vozeh S, Thiel G, Brunner F, Loertscher R, et al. Intravenous cyclosporine kinetics in renal failure. Clin Pharmacol Ther. 1983; 34: 638-43. [PMID: 6627824] / Munar MY, Doyle IC, Meyer MM. Cyclosporine and vancomycin disposition during continuous venovenous hemodiafiltration. Ann Pharmacother. 1995; 29: 374-7. [PMID: 7633014] / Rodighiero V. Therapeutic drug monitoring of cyclosporin. Practical applications and limitations. Clin Pharmacokinet. 1989; 16: 27-37. [PMID: 2650953]
Toxicity Notes
Nephrotoxic. Hypertension; seizures and tremors. Inhibitors of hepatic metabolism may increase blood concentration and cause high blood levels and toxicity. Multiple drug interactions.