Excreted Unchanged %
70-90
Half-Life (Normalesrd) Hours
13/51
Plasma Protein Binding %
36
Volume Of Distribution L/Kg
0.25
Dose For Normal Renal Function
3-10 mg/kg
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
25-50% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Conrad KA, Lee SM. Clodronate kinetics and dynamics. Clin Pharmacol Ther. 1981; 30: 114-20. [PMID: 6453676] / Saha H, Castren-Kortekangas P, Ojanen S, Juhakoski A, Tuominen J, Tokola O, et al. Pharmacokinetics of clodronate in renal failure. J Bone Miner Res. 1994; 9: 1953-8. [PMID: 7872061]
Toxicity Notes
Hyperchloremic acidosis.