Half-Life (Normalesrd) Hours
7-10/Unchanged
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
2.4
Dose For Normal Renal Function
5-10 mg tid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Wiseman LR, Faulds D. Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders. Drugs. 1994; 47: 116-52. [PMID: 7510617]
Toxicity Notes
Generally unavailable in the US because of fatal arrhythmias and prolonged QT intervals.Contraindicated in renal failure patients.