Half-Life (Normalesrd) Hours
0.8-3.2/Unchanged
Plasma Protein Binding %
40-60
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
10-40 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Halstenson CE, Triscari J, DeVault A, et al. Single-dose pharmacokinetics of pravastatin in patients with renal insufficiency. J Clin Pharm. 1992; 32: 124-32.