Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
0.5-1/Unknown
Plasma Protein Binding %
No data
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
1-2 g tid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
25% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Gokal R, Mann JI, Oliver DO, Ledingham JG, Carter RD. Treatment of hyperlipidaemia in patients on chronic haemodialysis. Br Med J. 1978; 1: 82-3. [PMID: 620211]
Toxicity Notes
Toxic reactions frequent in ESRD. Aspirin may attenuate flushing.