Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
1.1-1.7/Unchanged
Plasma Protein Binding %
>95
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
20-80 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, [D]
References
Henwood JM, Heel RC. Lovastatin. A preliminary review of its pharmacodynamic properties and therapeutic use in hyperlipidaemia. Drugs. 1988; 36: 429-54. [PMID: 3069436]
Toxicity Notes
Rhabdomyolysis rarely. Interacts with calcineurin inhibitor class of immunosuppressives.