Half-Life (Normalesrd) Hours
0.5-1/No data
Plasma Protein Binding %
98
Volume Of Distribution L/Kg
0.42
Dose For Normal Renal Function
2-10 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Dose for GFR 10-50, not on market
References
Jokubaitis LA. Updated clinical safety experience with fluvastatin. Am J Cardiol. 1994; 73: 18D-24D. [PMID: 8198019]
Toxicity Notes
Liver dysfunction is rare. Myositis and rhabdomyolysis are rare occurences. Drug interactions with calcineurin inhibitors for transplant.