Excreted Unchanged %
40-70
Half-Life (Normalesrd) Hours
15.0-17.5/30-110
Plasma Protein Binding %
92-97
Volume Of Distribution L/Kg
0.14
Dose For Normal Renal Function
500-1000 mg bid
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
q6-12h [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
q12-18h [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Gugler R. Clinical pharmacokinetics of hypolipidaemic drugs. Clin Pharmacokinet. 1978; 3: 425-39. [PMID: 363332]
Toxicity Notes
Impairs water excretion. Myostitis.