General Toxicity Notes
Avoid all oral hypoglycemic agents on CRRT.
Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
4-6/Unchanged
Plasma Protein Binding %
95-97
Volume Of Distribution L/Kg
0.1-0.15
Dose For Normal Renal Function
1-2 g q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Nelson E. Rate of metabolism of tolbutamide in test subjects with liver disease or with impaired renal function. Am J Med Sci. 1964; 248: 657-9. [PMID: 14251902]
Toxicity Notes
May impair water excretion.