General Toxicity Notes
Avoid all oral hypoglycemic agents on CRRT.
Excreted Unchanged %
90-100
Half-Life (Normalesrd) Hours
1-5/Prolonged
Plasma Protein Binding %
Negligible
Volume Of Distribution L/Kg
1-4
Dose For Normal Renal Function
500-850 mg bid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
50% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
25% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not applicable, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Avoid
References
Dunn CJ, Peters DH. Metformin. A review of its pharmacological properties and therapeutic use in non-insulin-dependent diabetes mellitus. Drugs. 1995; 49: 721-49. [PMID: 7601013]
Toxicity Notes
Lactic acidosis.