General Toxicity Notes
Avoid all oral hypoglycemic agents on CRRT.
Half-Life (Normalesrd) Hours
1.4-2.9/5
Plasma Protein Binding %
99
Volume Of Distribution L/Kg
0.16-0.3
Dose For Normal Renal Function
1.25-20 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
No data
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
No data
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None
Supplement For Dialysis [Recommendation Level]: Pd
PD: None
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Feldman JM. Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects. Pharmacotherapy. 1985; 5: 43-62. [PMID: 3923453]