General Toxicity Notes
Avoid all oral hypoglycemic agents on CRRT.
Excreted Unchanged %
4.5-7
Half-Life (Normalesrd) Hours
3-7/No data
Plasma Protein Binding %
97
Volume Of Distribution L/Kg
0.13-0.16
Dose For Normal Renal Function
2.5-15 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
50% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
50% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Dose for GFR <10, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Lebovitz HE. Glipizide: a second-generation sulfonylurea hypoglycemic agent. Pharmacology, pharmacokinetics and clinical use. Pharmacotherapy. 1985; 5: 63-77. [PMID: 3923454] / Wensing G. Glipizide: an oral hypoglycemic drug. Am J Med Sci. 1989; 298: 69-71. [PMID: 2665487]