General Toxicity Notes
Avoid all oral hypoglycemic agents on CRRT.
Half-Life (Normalesrd) Hours
24-48/50-200
Plasma Protein Binding %
88-96
Volume Of Distribution L/Kg
0.09-0.27
Dose For Normal Renal Function
100-500 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
50% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: Avoid, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Taylor JA. Pharmacokinetics and biotransformation of chlorpropamide in man. Clin Pharmacol Ther. 1972; 13: 710-8. [PMID: 5053812]
Toxicity Notes
Impairs water excretion. Prolonged hypoglycemia in azotemic patients.