General Toxicity Notes
Avoid all oral hypoglycemic agents on CRRT.
Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
1.0-1.3/Prolonged
Plasma Protein Binding %
65-90
Volume Of Distribution L/Kg
0.21
Dose For Normal Renal Function
250-1500 mg q24h
Adjustment For Renal Failure Method
I
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Baba S, Baba T, Iwanaga T. Effect of acetohexamide (a sulfonylurea hypoglycemic agent) in blood plasma on creatinine assay in clinical laboratory tests. Chem Pharm Bull (Tokyo). 1979; 27: 139-43. [PMID: 428022]
Toxicity Notes
Diuretic effect. May falsely elevate serum creatinine. Active metabolite has T1/2 of 5-8 hours in healthy subjects and is eliminated by the kidney. Prolonged hypoglycemia in azotemic patients.