General Toxicity Notes
Avoid all oral hypoglycemic agents on CRRT.
Half-Life (Normalesrd) Hours
3-9/Prolonged
Plasma Protein Binding %
15
Volume Of Distribution L/Kg
0.32
Dose For Normal Renal Function
50-200 mg tid
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
50-100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
Avoid [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
Avoid [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: No data
Supplement For Dialysis [Recommendation Level]: Pd
PD: No data
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Balfour JA, McTavish D. Acarbose. An update of its pharmacology and therapeutic use in diabetes mellitus. Drugs. 1993; 46: 1025-54. [PMID: 7510610]