General Toxicity Notes
May aggravate azotemia, Na+ retention, glucose intolerance, hypertension.
Half-Life (Normalesrd) Hours
2.5-3.5/Unchanged
Plasma Protein Binding %
Up to 80
Volume Of Distribution L/Kg
2.2
Dose For Normal Renal Function
5-60 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Yes, [B]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [B]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Bergrem H. Pharmacokinetics and protein binding of prednisolone in patients with nephrotic syndrome and patients undergoing hemodialysis. Kidney Int. 1983; 23: 876-81. [PMID: 6887699] / Legler UF, Frey FJ, Benet LZ. Prednisolone clearance at steady state in man. J Clin Endocrinol Metab. 1982; 55: 762-7. [PMID: 7107818] / Pickup ME. Clinical pharmacokinetics of prednisone and prednisolone. Clin Phar-macokinet. 1979; 4: 111-28. [PMID: 378499]