General Toxicity Notes
May aggravate azotemia, Na+ retention, glucose intolerance, hypertension.
Half-Life (Normalesrd) Hours
1.9-6.0/Unchanged
Plasma Protein Binding %
40-60
Volume Of Distribution L/Kg
1.2-1.5
Dose For Normal Renal Function
4-48 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [A]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [A]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Yes, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]
References
Al-Habet SM, Rogers HJ. Methylprednisolone pharmacokinetics after intravenous and oral administration. Br J Clin Pharmacol. 1989; 27: 285-90. [PMID: 2655680]