General Toxicity Notes
May aggravate azotemia, Na+ retention, glucose intolerance, hypertension.
Excreted Unchanged %
None
Half-Life (Normalesrd) Hours
0.5-2/3.5
Plasma Protein Binding %
90
Volume Of Distribution L/Kg
No data
Dose For Normal Renal Function
25-500 mg q24h
Adjustment For Renal Failure Method
D
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [D]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [D]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [B]
References
Bellomo R, McGrath B, Boyce N. Effect of continuous venovenous hemofiltration with dialysis on hormone and catecholamine clearance in critically ill patients with acute renal failure. Crit Care Med. 1994; 22: 833-7. [PMID: 8181293] / Tsubo T, Hashimoto Y, Araki I, Ishihara H, Matsuki A. Cortisol and catecholamine kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction syndrome. Intensive Care Med. 1996; 22: 1176-8. [PMID: 9120109]