Half-Life (Normalesrd) Hours
2.3/Unchanged
Plasma Protein Binding %
>90
Volume Of Distribution L/Kg
2.3
Dose For Normal Renal Function
600 mg qid
Adjustment For Renal Failure Gfr, Ml/Min >50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min 10-50 [Recommended Level]
100% [B]
Adjustment For Renal Failure Gfr, Ml/Min <10 [Recommended Level]
100% [B]
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: None, [D]
Supplement For Dialysis [Recommendation Level]: Pd
PD: None, [D]
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not applicable
References
Awni WM, Wong S, Chu SY, Patterson K, Hansen R, Machinist JM, et al. Pharmacokinetics of zileuton and its metabolites in patients with renal impairment. J Clin Pharmacol. 1997; 37: 395-404. [PMID: 9156372]